Epidermal growth factor upregulates -adrenergic receptor signaling in a human salivary cell line
نویسندگان
چکیده
Chih-Ko Yeh,1,2 Tazuko K. Hymer,1 April L. Sousa,1 Bin-Xian Zhang,3,4 Meyer D. Lifschitz,3,4 and Michael S. Katz1,4 1Geriatric Research, Education and Clinical Center, and 3Research Service, South Texas Veterans Health Care System, Audie L. Murphy Division, San Antonio 78229-4404; and Departments of 2Dental Diagnostic Science and 4Medicine, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900
منابع مشابه
Epidermal growth factor upregulates beta-adrenergic receptor signaling in a human salivary cell line.
The effects of epidermal growth factor (EGF) on the beta-adrenergic receptor-coupled adenylyl cyclase system were studied in a human salivary cell line (HSY). The beta-adrenergic agonist isoproterenol (10(-5) M) stimulated adenylyl cyclase activity by approximately 2-fold, and the isoproterenol response was increased 1.8-fold after prolonged (48 h) exposure to EGF (5 x 10(-10) M). In contrast, ...
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